名稱：毛細管柱

固定液：聚乙二醇-20M

規格：30m*0.32mm*0.5um

型號：HH-WAX

N-乙基吡咯烷酮(NEP)是一種無色透明的液體,沸點82-83℃( 101.3Kpa)，相對密度 0.994g/cm3，折光率1.4665 ( 22℃)。是一種強極性的有機溶劑。具有髙化學穩定性、弱堿性、出眾溶解能力、低蒸汽壓及低介電常數。不會形成氫鍵，屬于極性非質子傳遞溶劑，可以取代其他穩定性差、蒸汽壓髙毒性大極易滲人皮膚的溶劑，被稱為無毒超溶劑。

合成N-乙基吡咯烷酮的方法有吡咯烷酮法和γ-丁內酯法。吡咯烷酮法由于反應需要鹵代垸烴參與并生產相應鹵化物，同時鹵代物對反應釜的選材也比較髙。γ-丁內酯法，由伯胺和γ-丁內酯縮合制得N-烷基-2-吡咯烷酮。該法收率相對比較高，但是工藝條件要求苛刻一些。

它可用作髙效選擇性溶劑、催化劑及陽離子表面活性劑,亦可作為基礎原料生產醫藥中間體。可用于精制油品及生產火藥、醫藥、染料、農藥、日化、涂料和耐熱樹脂等。


浩瀚色譜（山東）應用技術開發有限公司  ，研發HH-WAX毛細管柱測定N-乙基吡咯烷酮，面積歸一法定量，結果準確。


Determination of N-Ethylpyrrolidone by Capillary Column
Capillary Column Determination of N-Ethylpyrrolidone Details:

Name: capillary column

Fixative: polyethylene glycol-20M

Specifications: 30m*0.32mm*0.5um

Model: HH-WAX

N-Ethylpyrrolidone (NEP) is a colorless and transparent liquid with a boiling point of 82-83°C ( 101.3Kpa), a relative density of 0.994g/cm3 and a refractive index of 1.4665 ( 22°C). It is a strong polar organic solvent. It has high chemical stability, weak alkalinity, excellent solubility, low vapor pressure and low dielectric constant. It does not form hydrogen bonds and is a polar aprotic solvent. It can replace other solvents with poor stability, high vapor pressure and high toxicity and can easily penetrate into the skin. It is called a non-toxic supersolvent.

The methods for synthesizing N-ethylpyrrolidone include pyrrolidone method and γ-butyrolactone method. The pyrrolidone method requires halogenated hydrocarbons to participate in the reaction and produces corresponding halides, and the selection of halides for the reaction kettle is also relatively high. γ-Butyrolactone method, N-alkyl-2-pyrrolidone is prepared by condensation of primary amine and γ-butyrolactone. The yield of this method is relatively high, but the process conditions are stricter.

It can be used as a high-efficiency selective solvent, catalyst and cationic surfactant, and can also be used as a basic raw material to produce pharmaceutical intermediates. It can be used for refined oil products and the production of gunpowder, medicine, dyes, pesticides, daily chemicals, coatings and heat-resistant resins.


Haohan Chromatography (Shandong) Application Technology Development Co., Ltd. keeps pace with the times and develops the HH-WAX capillary column for the determination of N-ethylpyrrolidone, which is quantified by the area normalization method, and the results are accurate and reliable.